Extraction method and detection method of total nitrosamines in cosmetics

The invention provides an extraction method and a detection method of total nitrosamine in cosmetics. The extraction method comprises the following steps: precisely weighing 0.5 to 1.0 g of the cosmetic, adding 50 to 150 [mu] L of a sulfamic acid aqueous solution with a concentration of 0.05 to 0.15...

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Main Authors HAN JING, ZHANG KAI, HUI TAICHENG, PENG XINGSHENG, JIAN LONGHAI, ZHENG RONG, YU LING, WANG KE, WU SILIN
Format Patent
LanguageChinese
English
Published 26.08.2022
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The invention provides an extraction method and a detection method of total nitrosamine in cosmetics. The extraction method comprises the following steps: precisely weighing 0.5 to 1.0 g of the cosmetic, adding 50 to 150 [mu] L of a sulfamic acid aqueous solution with a concentration of 0.05 to 0.15 g/mL and 1 to 3 mL of tetrahydrofuran, and carrying out vortex oscillation for 1 to 3 min; adding a water-methanol-acetonitrile-tetrahydrofuran mixed solution until the total volume is 9mL, carrying out vortex oscillation for 1-3 minutes, carrying out ultrasonic treatment for 20-40 minutes at the temperature of 30-50 DEG C, and cooling to room temperature; adding a water-methanol-acetonitrile-tetrahydrofuran mixed solution until the total volume is 10mL, carrying out vortex oscillation for 1-3 minutes, carrying out centrifugal treatment for 5-10 minutes at the speed of 5000r/min-14000r/min, and taking supernate, so as to obtain the compound. The method disclosed by the invention is high in total nitrosamine extrac
Bibliography:Application Number: CN202210462080