Preparation method and application of platinum prodrug induced photo-crosslinking hydrogel

• Main Authors: FAN LU, SHEN XIAN, KUANG GAIZHEN, ZHAO YUANJIN, ZHANG QINGFEI
• Format: Patent
• Language: Chinese; English
• Published: 26.08.2022
• Subjects: ADDITIVE MANUFACTURING TECHNOLOGY; ADDITIVE MANUFACTURING, i.e. MANUFACTURING OFTHREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVEAGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING,STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRANSPORTING; WORKING-UP

The invention provides a preparation method of platinum prodrug induced photo-crosslinking hydrogel, which specifically comprises the following steps: sequentially carrying out substitution reaction on cis-platinum through pyridine, AgNO3 and NaN3, and then oxidizing through hydrogen peroxide to obtain a photosensitive tetravalent platinum prodrug; the preparation method comprises the following steps: mixing a light-sensitive tetravalent platinum prodrug with a methacrylated gelatin solution, and uniformly stirring to obtain a pre-gel solution; the pre-gel solution is directly subjected to ultraviolet irradiation, and the platinum prodrug induced photo-crosslinking hydrogel is obtained; or filling the pre-gel solution into an injection pump, and carrying out 3D printing under ultraviolet irradiation to obtain the platinum prodrug induced photo-crosslinking hydrogel 3D printing drug stent. The light-sensitive platinum prodrug is used as a photoinitiator to induce polymer crosslinking to prepare the photo-cross