Use of hepatic progenitor cells or stem cells, lysates thereof and/or conditioned media for conditions characterized by hypervascular permeability

• Main Authors: PHANE, HOLMAN STEVE, CORITORE, EUGENIO, SOKAL ETIENNE, MICHEL, ST
• Format: Patent
• Language: Chinese; English
• Published: 19.08.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to hepatic progenitor cells or stem cells, lysates thereof and/or conditioned media obtainable by culturing hepatic progenitor cells or stem cells in a medium, the present invention relates to compounds for use in the treatment of diseases and/or conditions resulting from increased vascular permeability, or in the recovery of vascular integrity of cells or tissues in a subject following inflammation and/or infection in the subject. More particularly, the present invention relates to hepatic progenitor cells or stem cells or conditioned media obtainable by culturing hepatic progenitor cells or stem cells in media for therapeutic use in sepsis and sepsis-induced diseases such as myocardial edema, acute kidney injury and lung sepsis. 本发明涉及肝祖细胞或干细胞、其裂解物和/或通过在培养基中培养肝祖细胞或干细胞可获得的条件培养基，其应用于治疗由血管通透性增加导致的疾病和/或病况、或用于恢复在受试者的炎症和/或感染后的受试者中的细胞或组织的血管完整性。更特别地，本发明涉及肝祖细胞或干细胞或通过在培养基中培养肝祖细胞或干细胞可获得的条件培养基，用于脓毒症和脓毒症诱导的疾病如心肌水肿、急性肾损伤和肺脓毒症中的治疗应用。