Carbazole reactive fluorine ion fluorescent probe based on rhodanine ring as well as preparation method and application of carbazole reactive fluorine ion fluorescent probe

• Main Authors: YUE YI, YAN LONGJIA, TU SAN, DING YUYU, LI DAN, LIU LI
• Format: Patent
• Language: Chinese; English
• Published: 16.08.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; ADHESIVES; CHEMISTRY; DYES; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEASURING; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; PAINTS; PHYSICS; POLISHES; TESTING

The invention relates to the technical field of detection, in particular to a rhodanine ring-based carbazole reactive fluorine ion fluorescent probe as well as a preparation method and application thereof. According to the invention, carbazole is used as a fluorophore, a silicon-oxygen bond is used as a recognition group, a rhodanine ring is introduced through a Knoevenagel condensation reaction, and a compound 5-((2-((tert-butyldimethylsilyl) oxy)-9-propyl-9H-carbazole-3-yl) methylene)-3-ethyl-2-thiothiazolidine-4-ketone is synthesized. The obtained fluorine ion fluorescent probe SCT can generate a remarkable fluorescent signal after responding to fluorine ions, and can be used for quantitative detection of trace fluorine ions in a polar solution; the fluorescent probe has long emission wavelength, can effectively reduce the influence of biological self-luminescence on the detection result, and can be used for living cell fluorescence imaging. 本发明涉及检测技术领域，具体是一种基于绕丹宁环的咔唑类反应型氟离子荧光探针及其制备方法与应用。本发明以咔唑为荧光团，硅氧键为识别基