Eicosapentaenoic acid compounded sodium hyaluronate injection for treating osteoarthritis

• Main Authors: WANG ZHAO, YANG QIHAO, JING YIHAN
• Format: Patent
• Language: Chinese; English
• Published: 12.08.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a sodium hyaluronate injection compounded with eicosapentaenoic acid for treating osteoarthritis and a preparation method of the sodium hyaluronate injection, and relates to the technical field of medicines. The injection provided by the invention is prepared by mixing an eicosapentaenoic acid nano-emulsion and a sodium hyaluronate solution. According to the sodium hyaluronate injection compounded with eicosapentaenoic acid, the normal viscoelasticity of synovial fluid can be recovered through sodium hyaluronate, the effects of lubrication and osmotic pressure buffering are achieved, meanwhile, eicosapentaenoic acid can be brought into the articular cartilage microenvironment, the bone joint progress is slowed down by adjusting inflammatory response, and the osteoarticular effect is improved. The effect of treating osteoarthritis is achieved. 本发明提供一种用于治疗骨关节炎的复合二十碳五烯酸的玻璃酸钠注射液及其制备方法，涉及医药技术领域。本发明的注射液其由二十碳五烯酸纳米乳液和玻璃酸钠溶液混合而成。本发明的复合二十碳五烯酸的玻璃酸钠注射液，不仅可以通过玻璃酸钠恢复关节液的正常粘弹性起到润滑和渗透压缓冲的作用，同时还可将二十碳五烯酸