一种多核铈纳米材料的合成方法及其应用

本发明公开了一种多核铈纳米材料的合成方法及其应用，属于纳米材料领域。该多核铈纳米材料为铈簇纳米粒子，具有十二个铈和十八个金刚烷，通过其表面的金刚烷与环糊精主客体自组装改性得到水溶性多核铈纳米材料，该水溶性多核铈纳米材料同时含有三价铈和四价铈，可以有效清除多种ROS(如·OH、H2O2、O2-)以及模拟多种酶活性(如CAT酶、SOD酶)，具有可调节的催化活性、易于制备且低成本、稳定性高、表面易修饰和可长期保存等优势，可用于ROS过量导致的炎症性疾病治疗方面。 The invention discloses a synthesis method and application of a multi...

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Bibliographic Details
Format Patent
LanguageChinese
Published 02.05.2023
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:本发明公开了一种多核铈纳米材料的合成方法及其应用，属于纳米材料领域。该多核铈纳米材料为铈簇纳米粒子，具有十二个铈和十八个金刚烷，通过其表面的金刚烷与环糊精主客体自组装改性得到水溶性多核铈纳米材料，该水溶性多核铈纳米材料同时含有三价铈和四价铈，可以有效清除多种ROS(如·OH、H2O2、O2-)以及模拟多种酶活性(如CAT酶、SOD酶)，具有可调节的催化活性、易于制备且低成本、稳定性高、表面易修饰和可长期保存等优势，可用于ROS过量导致的炎症性疾病治疗方面。 The invention discloses a synthesis method and application of a multi-core cerium nano material, and belongs to the field of nano materials. The multi-core cerium nano-material is cerium cluster nano-particles and has twelve cerium and eighteen adamantanes, the water-soluble multi-core cerium nano-material is obtained through subject-object self-assembly modification of the adamantanes on the surfaces of the cerium cluster nano-particles and cyclodextrin, and the water-soluble multi-core cerium nano-material simultaneously contains trivalent cerium and tetravalent cerium. The compound can effectively remove various ROS (such as. OH, H2O2 and O2 <->) and simulate various enzyme activities (such as CAT enzyme and SOD enzyme), has the advantages of adjustable catalytic activity, easine
Bibliography:Application Number: CN202210374163