Method for preparing 2, 2, 6, 6-tetramethyl-4-piperidone

• Main Authors: HU XINLI, CAI HONGYUN, XIANG ZHANBO, ZHAO XIAOFENG, SHI XIAO, CHEN YIFAN
• Format: Patent
• Language: Chinese; English
• Published: 05.08.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a method for preparing 2, 2, 6, 6-tetramethyl-4-piperidone, in particular to a method for preparing 2, 2, 6, 6-tetramethyl-4-piperidone. The method comprises the following steps: (1) respectively adding acetone and a catalyst into a reaction kettle, introducing ammonia gas or ammonia water into the reaction kettle while stirring, controlling the kettle temperature at 40-90 DEG C, and carrying out heat preservation reaction for 3-20 hours; (2) opening cooling water for cooling until the temperature of the reaction liquid is less than 40 DEG C; (3) stopping stirring, and standing for 1 hour to obtain a 2, 2, 6, 6-tetramethyl-4-piperidone crude product; feeding the crude product into a rectifying tower, and rectifying to obtain a high-purity 2, 2, 6, 6-tetramethyl-4-piperidone product; the catalyst adopted by the invention is one or a mixture of more of acyl halide or acyl halide compounds containing substituent groups, the yield of 2, 2, 6, 6-tetramethyl-4-piperidone is high, and the pr