Preparation method of sodium valproate and valproic acid eutectic crystal and product of sodium valproate and valproic acid eutectic crystal

• Main Authors: ZHOU FENGSHU, YANG HAIFENG, WU YUHUI
• Format: Patent
• Language: Chinese; English
• Published: 05.08.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the field of preparation of valproic acid and salts thereof, and discloses a preparation method of a sodium valproate and valproic acid eutectic crystal, which comprises the following steps: S1, mixing at least one of sodium hydroxide, sodium carbonate and sodium bicarbonate with valproic acid to form an aqueous solution at 50-140 DEG C, wherein the total molar weight of the sodium hydroxide, the sodium carbonate, the sodium bicarbonate or the mixture thereof is 0.4-0.8 of the molar weight of the valproic acid; s2, evaporating the water solution formed in the step S1 to remove water, and then cooling, condensing and crystallizing; and S3, crushing the crystal in the step S2 into particles or powder to obtain the sodium valproate and valproic acid eutectic crystal. According to the preparation method, water is directly adopted to form an aqueous solution, an organic solvent is avoided for refining, the exposure time of materials in the process is short, strict control over the environm