Polypeptide molecular probe for targeting CD19 antibody and application of polypeptide molecular probe

• Main Authors: ZHANG BO, YANG MIN, WANG GUANGJI, PAN DONGHUI, WANG XINYU, YAN JUNJIE, ZHAO FUKUAN, XU YUPING, WANG LIZHEN
• Format: Patent
• Language: Chinese; English
• Published: 05.08.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

The invention discloses a polypeptide molecular probe of a targeted CD19 antibody and application of the polypeptide molecular probe. The polypeptide molecular probe is one or more of compounds with the following chemical structures, or pharmaceutically acceptable salts of the compounds, namely P1-Rn, P2-Rn, P3-Rn, P4-Rn, P5-Rn and P6-Rn. The molecular probe of the targeted CD19 antibody developed by the invention can trace the in-vivo transport process, tumor targeting ability, in-vivo proliferation and persistence of a cell therapy, is beneficial to monitoring the effectiveness and safety of the cell therapy in the whole process, and has important clinical value in the aspects of curative effect evaluation and therapeutic schedule guidance. 本发明公开了一种靶向CD19抗体的多肽分子探针及其应用，所述多肽分子探针，具有以下化学结构的化合物中的一种或几种，或它们在药学上可接受的盐，P1-Rn，P2-Rn，P3-Rn，P4-Rn，P5-Rn，P6-Rn。本发明开发的靶向CD19抗体的分子探针能够示踪细胞疗法体内输运过程、肿瘤靶向能力、体内增殖和持续性，有助于全过程监测细胞疗法的有效性及安全性，在疗效评估、治疗方案指导方面有着重要的临床价值。