Anti-HER2 polypeptide derivative as novel diagnostic molecular probe

The present invention provides novel polypeptide derivatives and conjugates thereof that bind to human epidermal growth factor receptor 2 (HER2), and their use as diagnostic agents, in particular for early detection of cancer forms characterized by overexpression of HER2, patient stratification, and...

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Main Authors BERGHI LUCA, CRIVELLIN FEDERICO, SCHINNIER MICHAEL, REITANO EMANUELE, MAIOCCHI ALESSANDRO, HEWITT SPENCER, KITTEN OLIVIER
Format Patent
LanguageChinese
English
Published 29.07.2022
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention provides novel polypeptide derivatives and conjugates thereof that bind to human epidermal growth factor receptor 2 (HER2), and their use as diagnostic agents, in particular for early detection of cancer forms characterized by overexpression of HER2, patient stratification, and treatment monitoring. 本发明提供了与人表皮生长因子受体2(HER2)结合的新多肽衍生物及其缀合物，以及它们作为诊断剂的用途，特别是用于以HER2的过表达为特征的癌症形式的早期检测、患者分层和治疗监测。
Bibliography:Application Number: CN202080088376