Compound for inhibiting and inducing degradation of EGFR kinase

Provided are EGFR kinase inhibitors of general formula (I), as well as pharmaceutical compositions containing said inhibitors, which are useful in the treatment of diseases associated with EGFR kinase, such as cancer; the invention also provides preparation and application of the inhibitor. 提供通式(I)的...

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Main Authors WANG YEMING, WANG HONGJUN, FAN FUTIAN, LIANG HUINING, LIU XUELIAN, ZHAO YANPING, WANG XIAOQIAN, JIANG YUANYUAN, XIE YONG, ZHANG YANHAO
Format Patent
LanguageChinese
English
Published 29.07.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are EGFR kinase inhibitors of general formula (I), as well as pharmaceutical compositions containing said inhibitors, which are useful in the treatment of diseases associated with EGFR kinase, such as cancer; the invention also provides preparation and application of the inhibitor. 提供通式(I)的EGFR激酶抑制剂，以及含有所述抑制剂的药物组合物，它们可用于治疗与EGFR激酶相关的疾病，例如癌症；还提供上述抑制剂的制备和用途。
Bibliography:Application Number: CN202080086636