Method for preparing 4-iodoisoquinoline-1 (2H)-ketone compound

• Main Authors: HUANG GUOLI, YANG CAIYUN, LI XIA
• Format: Patent
• Language: Chinese; English
• Published: 29.07.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the field of organic synthetic chemistry, and discloses a method for preparing 4-iodoisoquinoline-1 (2H)-ketone compounds, which takes isoquinoline-1 (2H)-ketone or derivatives thereof as a substrate, takes acid as an only catalyst, and reacts with iodosuccinimide (NIS) in a solvent at a certain reaction temperature to obtain the 4-iodoisoquinoline-1 (2H)-ketone compounds. According to the scheme, common inorganic acid or organic acid which is low in price and easy to obtain is adopted as a reaction catalyst, no metal or organic catalyst is used, no oxidizing agent or additive is needed, the reaction condition is mild, the product yield is high, operation is easy, and environment friendliness is achieved; the used reagent and catalyst have abundant industrial sources and are easy to obtain, the production cost is low, the product purity is high, and the method has a good industrial application prospect. 本方案属于有机合成化学领域，公开了一种制备4-碘异喹啉-1(2H)-酮类化合物的方法，其以异喹啉-1(2H)-酮或其衍生物为底物，以酸为仅有的催化剂，与碘代丁二酰亚