(-)-cis-tetrahydrocannabinol ((-)-cis-THC) for use as medicament

• Main Authors: KNAPPERTZ, VOLKER, GUY GEOFFREY, WOOLLEY-ROBERTS, MARY, WHALLEY BENJAMIN
• Format: Patent
• Language: Chinese; English
• Published: 22.07.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to tetrahydrocannabinol (THC) type cannabinoid compounds for use as medicaments. The THC-type cannabinoid is an enantiomer of (-)-trans-tetrahydrocannabinol, which is a naturally occurring cannabinoid, which can be found in cannabis plant lines that have been cultivated to produce THC as the major cannabinoid. It has been found that the specific enantiomer (-)-cis-tetrahydrocannabinol has properties different from those of (-)-trans-THC which is naturally occurring. It has been found that cannabinoid (-)-cis-THC is present at low concentrations in specific cannabis plant lines that have been cultivated to produce cannabidiol (CBD) as the major cannabinoid. In addition, cannabinoids can be produced by a synthetic means. 本发明涉及用作药物的四氢大麻酚(THC)型大麻素化合物。THC型大麻素是(-)-反式-四氢大麻酚的对映异构体，(-)-反式-四氢大麻酚是天然存在的大麻素，其可以在已经被培育成产生THC作为主要大麻素的大麻属植物品系中找到。已经发现特定的对映异构体(-)-顺式四氢大麻酚具有不同于天然存在的(-)-反式-THC的性质。已经发现大麻素(-)-顺式-THC在已经被培育成产生大麻二酚(CBD)作为主要大麻素的特定大麻属植物品系中以低浓度存在。此外，大麻素可以通过合成手段生产。