Polymer composite microcarrier and preparation method thereof

• Main Authors: CHEN JIAKE, BAO XIAOFAN, JIANG TAO
• Format: Patent
• Language: Chinese; English
• Published: 22.07.2022
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; GENERAL PROCESSES OF COMPOUNDING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC MACROMOLECULAR COMPOUNDS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; THEIR PREPARATION OR CHEMICAL WORKING-UP; VINEGAR; WINE; WORKING-UP

The invention relates to a polymer composite microcarrier and a preparation method thereof. The polymer composite microcarrier is composed of a synthetic high-molecular polymer of a spherical main body and natural macromolecules of a patch area, the preparation method comprises the following steps: dissolving natural macromolecules in water to obtain a solution as a primary emulsion dispersion phase W; dissolving a synthetic high-molecular polymer in a volatile organic solvent to obtain a solution as a primary emulsion continuous phase O; mechanically homogenizing the solution to obtain a water-in-oil primary emulsion as an inner channel fluid W/O; a hydrophilic surfactant is taken and dissolved in deionized water to serve as an outer channel fluid WO; enabling W/O and WO to respectively pass through the assembled two-phase microchannel to obtain a water-in-oil-in-water type composite emulsion; the obtained composite emulsion is received in an independent WO aqueous solution, standing is carried out for 24-72