Process and equipment for preparing ivabradine intermediate benzazepine skeleton

The invention relates to the field of medicine preparation, and particularly discloses a process and equipment for preparing an ivabradine intermediate benzazepine skeleton, the preparation process comprises the following steps: S1, taking benzocyclobutanone and N-heterocyclic propane as initial raw...

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Bibliographic Details
Main Authors ZHAO DONGBING, WANG ZHONGHUI
Format Patent
LanguageChinese
English
Published 22.07.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to the field of medicine preparation, and particularly discloses a process and equipment for preparing an ivabradine intermediate benzazepine skeleton, the preparation process comprises the following steps: S1, taking benzocyclobutanone and N-heterocyclic propane as initial raw materials, under the concerted catalysis of palladium/lewis acid, carrying out a reaction on the initial raw materials to obtain a crude product; the preparation method comprises the following steps: carrying out cross dimerization ring expansion reaction between benzocyclobutanone and N-heterocyclic propane to generate a Ts (p-toluenesulfonyl) protected benzoazepine ketone compound for later use; the preparation equipment comprises a polymerization reaction kettle, a reaction kettle cold water group, a liquid pump, an automatic potentiometric titrator, a chemical stirrer, a centrifugal extractor and a distillation kettle. The benzazepine ketone medical intermediates with various structures can be prepared on a la
Bibliography:Application Number: CN202210456543