Application of ICAM-1 polypeptide or gene in preparation of medicine for treating and repairing spermatogenesis disorder in testis

• Main Authors: QU HAOYANG, HAN YATING, XIAO XIANG, YAO MINGXIA
• Format: Patent
• Language: Chinese; English
• Published: 22.07.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention provides an application of ICAM-1 polypeptide or gene in preparation of a medicine for treating and repairing dyszoospermia in testis, and belongs to the technical field of biological medicines. The overexpression of the coding sequence of the ICAM-1 polypeptide can obviously improve the resistance level of the sertoli cells, repair damage to the barrier function of the sertoli cells caused by sICAM-1 expression increase, repair a cell connection structure formed between the sertoli cells, repair a microfilament cytoskeleton protein structure of the sertoli cells and repair dyszoospermia induced by sICAM-1 expression increase. Therefore, the invention provides a new treatment thought for repairing dyszoospermia induced by sICAM-1 expression increase in the testis. 本发明提供了ICAM-1多肽或基因在制备治疗修复睾丸中生精障碍的药物中的应用，属于生物药物技术领域。ICAM-1多肽的编码序列过表达能够明显提高睾丸支持细胞电阻水平，修复因sICAM-1表达升高所造成的支持细胞屏障功能受损，修复支持细胞之间形成的细胞连接结构，修复支持细胞的微丝细胞骨架蛋白结构，修复sICAM-1表达上升诱导的生精障碍。因此，本发明为修复睾丸中sICAM-1表达升高诱导的生精障碍的治疗提供了新的治疗思路。