Blood-based assays for site-specific tau phosphorylation-based diagnostics and therapies

The present disclosure provides for using a blood sample to quantify tau phosphorylation at a particular amino acid residue to predict the time from the onset of mild cognitive impairment caused by Alzheimer's disease, staging Alzheimer's disease, guiding treatment decisions, and determini...

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Bibliographic Details
Main Authors BATEMAN, RICHARD, BARTHELEMY NICOLAS
Format Patent
LanguageChinese
English
Published 15.07.2022
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:The present disclosure provides for using a blood sample to quantify tau phosphorylation at a particular amino acid residue to predict the time from the onset of mild cognitive impairment caused by Alzheimer's disease, staging Alzheimer's disease, guiding treatment decisions, and determining the onset of cognitive impairment caused by Alzheimer's disease. Methods of selecting subjects of a clinical trial and assessing the clinical efficacy of certain therapeutic interventions. 本公开提供了使用血液样品对特定氨基酸残基处的tau磷酸化进行定量以预测距由阿尔茨海默氏病引起的轻度认知损害发作的时间、对阿尔茨海默氏病进行分期、指导治疗决定、选择临床试验的受试者并评估某些治疗性干预的临床功效的方法。
Bibliography:Application Number: CN20208078091