Compositions and methods for enhancing immune response to vaccination and improving vaccine production

• Main Authors: CHAN FUK WOO JASPER, YUEN KWOK YUNG, YUAN SHUOFENG, LAU JOHNSON YIU-NAM, DU QIHONG, ZHANG JINXIA, KONG FANYI
• Format: Patent
• Language: Chinese; English
• Published: 15.07.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

Miltefosin is utilized to enhance immune responses to vaccinations, such as influenza and/or coronavirus vaccinations. The subject matter of the present invention also provides compositions and methods for increasing the yield of viruses in cells by applying a cannabinoid receptor agonist, such as methaneandamide, to the cultured cells. Such increased viral yields can be used to increase viral yield for vaccine formulation and/or to improve the sensitivity of cell-based viral assays. 利用米替福新来增强对疫苗接种，例如流感和/或冠状病毒疫苗接种的免疫反应。本发明主题还提供了通过将大麻素受体激动剂(如methanandamide)应用于培养细胞来提高此类细胞中病毒产率的组合物和方法。此类提高的病毒产率可以用于提高病毒产量以用于疫苗配制和/或改善基于细胞的病毒测定的灵敏度。