Vitamin K2-containing pharmaceutical composition for improving cardiovascular calcification as well as preparation method and application thereof

• Main Authors: HE TIANMING, SHI LUQIU, SU GUIZHEN, XUE HONGYU
• Format: Patent
• Language: Chinese; English
• Published: 15.07.2022
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY ASINGLE OTHER SUBCLASS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention provides a pharmaceutical composition containing vitamin K2 for improving cardiovascular calcification, which is composed of a composition I, a composition II and a composition III in a mass ratio of (0.1-5): (0.01-0.5): (100-500). The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition can comprehensively prevent and block cardiovascular calcification, is especially suitable for reversing cardiovascular calcification symptoms caused by taking statins, and provides a daily support and protection effect for heart health at the same time. The pharmaceutical composition disclosed by the invention has the advantages of stable active ingredients, high bioavailability, strong targeting property and no side effect, and can achieve the purposes of prevention and treatment at the same time. 本发明提供了一种含有维生素K2改善心血管钙化的药物组合物，所述药物组合物由组成物Ⅰ、组成物Ⅱ、组成物Ⅲ构成，其质量比为(0.1～5)：(0.01～0.5)：(100～500)。本发明还提供了该药物组合物的制备方法及其应用。所述药物组合物能全面预防和阻断心血管钙化，尤其适合于逆转由于服