Compositions and methods for enhancing immunotherapy and vaccine efficacy

• Main Authors: HAN KAI, HUANG XUEHUI, XU JIN, MOON, JAMES, J
• Format: Patent
• Language: Chinese; English
• Published: 08.07.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates generally to compositions and methods for enhancing the efficacy of immunotherapy and vaccines. In particular, the present invention relates to increasing the richness and diversity of the gut microbiome of a subject by administering an agent (e.g., a prebiotic agent comprising fibers (e.g., epigallocatechin gallate (EGCG), fucoidin, potato starch, fructo-oligosaccharide and synanthrin)) (e.g., melatonin) with an immunotherapy or vaccine. Such compositions and methods are useful for the treatment of cancer, infectious pathogens, autoimmune diseases, neurological disorders, and/or obesity. 本发明一般地涉及用于提高免疫疗法和疫苗功效的组合物和方法。尤其，本发明涉及通过施用药剂(例如，包含纤维的益生元剂(例如，表没食子儿茶素没食子酸酯(EGCG)、岩藻多糖、马铃薯淀粉、低聚果糖和菊糖))(例如,褪黑激素)与免疫疗法或疫苗来提升受试者肠道微生物组的丰富度和多样性。这样的组合物和方法可用于治疗癌症、感染性病原体、自身免疫性疾病、神经疾患和/或肥胖症。