Adeno-associated virus vector pharmaceutical compositions and methods

• Main Authors: T.MARSHALL, BEE JARED, DE PASO RODOLFO, OBERG KARL, ZHANG YI
• Format: Patent
• Language: Chinese; English
• Published: 08.07.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided herein are pharmaceutical compositions comprising a recombinant adeno-associated virus (AAV), a salt excipient or buffer, a sugar, and a surfactant. Also provided herein are methods for treating or preventing a disease in a subject by administering to the subject in need thereof a therapeutically effective amount of the pharmaceutical composition. 本文提供了包括重组腺相关病毒(AAV)、盐赋形剂或缓冲剂、糖和表面活性剂的药物组合物。本文还提供了用于通过向有需要的受试者施用治疗有效量的所述药物组合物来治疗或预防所述受试者的疾病的方法。