Cross-linked hyaluronic acid butyrate or butyrate-formate derivative and cross-linking method thereof

• Main Authors: MASTRODONATO MICHELE, GIANI RITA, PICOTTI FABRIZIO, STUCCHI LUCA, SECCHI ALESSANDRA
• Format: Patent
• Language: Chinese; English
• Published: 08.07.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a process for the preparation of a crosslinked hyaluronic acid butyrate or a crosslinked hyaluronic acid butyrate-formate or an acceptable salt thereof wherein the process comprises a crosslinking reaction of a hyaluronic acid butyrate or a hyaluronic acid butyrate-formate or a pharmaceutically acceptable salt thereof with a carboxyl activating agent in an organic solvent, the composition is characterized in that the hyaluronic acid butyrate or the hyaluronic acid butyrate-formate or the pharmaceutically acceptable salt thereof is a mixture of high-molecular-weight polysaccharide and low-molecular-weight polysaccharide. 本发明涉及制备交联透明质酸丁酸酯或交联透明质酸丁酸酯-甲酸酯或其可接受的盐的方法，其中所述方法包括透明质酸丁酸酯或透明质酸丁酸酯-甲酸酯或其药学上可接受的盐在有机溶剂中与羧基活化试剂的交联反应，其特征在于，所述透明质酸丁酸酯或透明质酸丁酸酯-甲酸酯或其药学上可接受的盐是高分子量多糖和低分子量多糖的混合物。