Substituted nitrogen-containing bicyclic compounds and uses thereof

• Main Authors: MA FACHENG, LIU CHUYI, ZHAN ZHIZHU, HE YAN, ZHANG ZHENG, ZUO YINGLIN, WANG XIAOJUN, CHI BO, HAN WEI, WANG HUI
• Format: Patent
• Language: Chinese; English
• Published: 28.06.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a substituted nitrogen-containing bicyclic compound and application thereof. Specifically, the invention relates to a class of novel substituted nitrogen-containing bicyclic compounds and a pharmaceutical composition containing the compounds, and the compounds and the pharmaceutical composition can be used as chymotrypsin inhibitors. The invention also relates to a method for preparing the compounds and the pharmaceutical composition, and application of the compounds and the pharmaceutical composition in preparation of drugs for treating cardiovascular diseases related to heart failure or myocardial infarction and the like. 本发明公开了取代的含氮双环化合物及其用途。具体地，本发明涉及一类新颖的取代的含氮双环化合物以及包含该类化合物的药物组合物，它们可作为类糜蛋白酶抑制剂。本发明还涉及制备这类化合物和药物组合物的方法，以及它们在制备治疗心力衰竭或心肌梗塞等有关心血管疾病的药物中的用途。