5-CF3-1, 2, 3-triazole compound as well as preparation method and application thereof

• Main Authors: FU SHIQIN, YUAN FANG, WU HAOXING, SUN HONGBAO, CHEN FENGFENG, DAI YUNFEI
• Format: Patent
• Language: Chinese; English
• Published: 28.06.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a 5-CF3-1, 2, 3-triazole compound as well as a preparation method and application thereof, and belongs to the technical field of medicines. The structure of the 5-CF3-1, 2, 3-triazole compound is as shown in a formula I in the specification. Experimental results show that the 5-CF3-1, 2, 3-triazole compound has an inhibition effect on various cancer cells including human ovarian cancer cells, human prostate cancer cells and human cervical cancer cells, and has a wide application prospect in preparation of drugs for preventing and/or treating cancers. The invention provides a method for preparing 5-CF3-1, 2, 3-triazole through copper-mediated trifluoromethylation reaction by taking 5-iodine-1, 2, 3-triazole and a difluorinated reagent as raw materials for the first time. The preparation method has the advantages of easily available raw materials, low cost, simple operation, safety and controllability, and the obtained product has high yield and high purity, and is suitable for industria