Chiral alpha-hydroxyl (ester) phosphate ester compound and preparation method thereof

• Main Authors: PEI CHENGXIN, GAO RUNLI, HU HUIJUAN, WANG HONGMEI
• Format: Patent
• Language: Chinese; English
• Published: 24.06.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a chiral alpha-hydroxyl (ester) phosphate ester compound and a preparation method thereof, and belongs to the field of organic chemistry. The compound is as shown in a formula I. Under the catalytic action of commercial lipase CALB, a racemic compound in a formula I-1 is subjected to bioconversion through kinetic resolution, and the optically pure alpha-hydroxyl (ester) phosphate compound I is efficiently and highly selectively obtained. The use amount of the lipase is adjusted according to the use amount of a substrate. The reaction system is a vinyl acetate solution (acyl donor), the temperature is 30-37 DEG C, and the reaction time is 16-432 hours. The method has the characteristics of simplicity and convenience in operation, high reaction efficiency, mild reaction conditions, high enantioselectivity, easiness in product separation and high product purity, and has a very good application prospect. 本发明公开了一类手性α-羟(酯)基磷酸酯类化合物及其制备方法，属于有机化学领域。该化合物如式I所示：在商业化的脂肪酶CALB的催化作用下，式I-1中的外消旋化合物通过动力学