香青兰中一个咖啡酸衍生物的制备方法及其用途

• Format: Patent
• Language: Chinese
• Published: 17.12.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

本发明公开了式Ⅱ所示的二苯并[b,f]噁庚英环类化合物或其药用盐在制备上调KLF2表达药物中的用途。本发明还公开了式Ⅱ所示的二苯并[b,f]噁庚英环类化合物或其药用盐在制备治疗心血管疾病或抗炎药物中的用途。发明人采用KLF2筛选模型对其进行心血管方面活性评价：以KLF2-COS7细胞为实验对象，首次发现二苯并[b,f]噁庚英环类化合物或其药用盐具有显著上调与动脉粥样硬化、抗炎等相关的靶点KLF2表达的活性，在治疗动脉粥样硬化相关疾病方面具有较好的应用前景。本发明还公开了所述的二苯并[b,f]噁庚英环类化合物的制备方法。#imgabs0# The invention discloses application of a dibenzo [b, f] oxepin ring compound shown in a formula II or a pharmaceutical salt thereof in preparation of a medicine for up-regulating KLF2 expression. The invention also discloses application of the dibenzo [b, f] oxepin ring compound as shown in the formula II or the pharmaceutical salt thereof in preparation of medicaments for treating cardiovascular diseases or resisting inflammation. The inventor performs cardiovascular activity evaluation on the dibenzo [b, f] oxepin ring compound by adopting a KLF2 screening model: KLF2-COS7 cells are taken as experimental subjects, and the dibenzo [b, f] oxepin ring compound or the pharmaceutical salt thereof is found to have the activity of remarkably up-re