Preparation method and application of caffeic acid derivative in dracocephalum moldavica

• Main Authors: XIAO TONGMEI, SU BINGJIE, SI SHUYI, ZHENG RUIFANG, LEI LIJUAN, CHEN YUCHUAN, YAN BIYING, LI YAN, XING JIANGUO, XU YANNI, CHEN MINGHUA, ZHANG JING
• Format: Patent
• Language: Chinese; English
• Published: 21.06.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of a dibenzo [b, f] oxepin ring compound shown in a formula II or a pharmaceutical salt thereof in preparation of a medicine for up-regulating KLF2 expression. The invention also discloses application of the dibenzo [b, f] oxepin ring compound as shown in the formula II or the pharmaceutical salt thereof in preparation of medicaments for treating cardiovascular diseases or resisting inflammation. The inventor performs cardiovascular activity evaluation on the dibenzo [b, f] oxepin ring compound by adopting a KLF2 screening model: KLF2-COS7 cells are taken as experimental subjects, and the dibenzo [b, f] oxepin ring compound or the pharmaceutical salt thereof is found to have the activity of remarkably up-regulating expression of target KLF2 related to atherosclerosis, inflammation resistance and the like for the first time; the compound has a good application prospect in the aspect of treating atherosclerosis related diseases. The invention also discloses a preparation meth