Anti-CD3 nucleic acid aptamers for cell targeting and labeling

• Main Authors: RIC, MIODEK, ANNA, MORAN, FR, D
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present application provides high affinity nucleic acid aptamer sequences that recognize CD3 protein complexes on the surface of a cell. The nucleic acid aptamer can be used as a targeting part of a delivery carrier, or used as a molecular component for immunotherapy and immunodiagnosis, or used for separating and purifying CD3 + T cells in a subject, or characterizing CD3 + T cells in a subject. 本申请提供了识别细胞表面上的CD3蛋白复合物的高亲和力核酸适配体序列。所述核酸适配体可以用作递送载体的靶向部分，或用作免疫治疗和免疫诊断的分子组分，或用于分离、纯化受试者中的CD3+T细胞，或表征受试者中的CD3+T细胞。