Aminoquinoline compounds, immunoconjugates and uses thereof

• Main Authors: SAFINA BRIAN, CHAU MARK, KUDYKA ROBERT
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides an immunoconjugate of formula (I) comprising an antibody linked by conjugation to one or more aminoquinoline derivatives. The present invention also provides an aminoquinoline derivative intermediate composition of formula (III), said aminoquinoline derivative intermediate composition comprising a reactive functional group. Such intermediate compositions are suitable matrices for forming the immunoconjugates via linkers or linking moieties. The invention also provides methods of treating cancer with the immunoconjugates. 本发明提供了式(I)的免疫缀合物，所述免疫缀合物包含通过与一种或多种氨基喹啉衍生物缀合而连接的抗体。本发明还提供了式(III)的氨基喹啉衍生物中间体组合物，所述氨基喹啉衍生物中间体组合物包含反应性官能团。此类中间体组合物是用于通过接头或连接部分形成所述免疫缀合物的合适基质。本发明还提供了用所述免疫缀合物治疗癌症的方法。