Reversed phase chromatography stationary phase with terminal polarity and preparation method of reversed phase chromatography stationary phase

• Main Authors: GUO ZHIMOU, ZHOU YONGZHENG, JIN GAOWA, YU DONGPING, LIANG XINMIAO, TANG HEYANG, HAN ZIWEI
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2022
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; SEPARATION; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention relates to a liquid chromatography stationary phase which is characterized in that the tail end of a bonded phase contains a polar group, and the structural formula of the bonded phase is shown in the specification, wherein Silica Gel is silica gel, m is equal to 1-30, and R is a halogen atom. The invention also provides a preparation method of the liquid chromatography stationary phase, and the surface of silica gel is modified by a horizontal polymerization method to prepare the pure water-resistant reversed-phase chromatography stationary phase containing the terminal polar group. The separation material provided by the invention is novel in structure, can improve the separation selectivity of alkyl chains, and is suitable for separation analysis of various compounds. 本发明涉及液相色谱固定相，其特征在于键合相中末端含有极性基团，其结构式如下：其中Silica Gel为硅胶，m＝1-30，R为卤素原子。本发明还提供了上述液相色谱固定相的制备方法，通过水平聚合的方法在硅胶表面进行修饰，制备得到含有末端极性基团的耐纯水的反相色谱固定相。本发明提供的分离材料结构新颖，可以改善烷基链的分离选择性，适用于各类化合物的分离分析。