Dimerization agent modulated immune receptor complexes

• Main Authors: LEUNG WAI-HANG, JARROUR, JORDAN, ASTRAKHAN ALEXANDER
• Format: Patent
• Language: Chinese; English
• Published: 10.06.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides adoptive T cell therapies having an improved DARIC architecture for targeting tumor antigens and recruiting TCR signaling complexes for treating, preventing, or ameliorating at least one symptom of cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or a condition associated therewith. 本公开提供了过继性T细胞疗法，所述过继性T细胞疗法具有用于靶向肿瘤抗原和募集TCR信号传导复合物的改善的DARIC架构，用于治疗、预防或改善癌症、传染病、自身免疫性疾病、炎性疾病和免疫缺陷的至少一种症状或与其相关的病状。