KRAS G12D INHIBITORS

• Main Authors: MEJIA MACEDONIO J, DAI DONGHUA, BLAKE JAMES FRANCIS, FELL JAY BRADFORD, WANG XIAOLUN, BURNS AARON CRAIG, NGUYEN PHU, CHRISTENSEN JAMES GAIL, SHELLEY ALLEN, SAVATCHENKOV, PAVEL, GAUDINO, JOHN, LAWSON JOHN DAVID, DEAN RUSSELL KAHN, NEWHOUSE, BRAD, O 'LEARY JACOB MATTHEW, CHICARELLI MARK JOSEPH, SMITH CHRISTOPHER RONALD, DAHLKE JOSHUA RYAN, TANG, TONY, P, VIGERS GUY P A, ZHAO QIAN, KETCHAM JOHN MICHAEL, MARX MATTHEW ARNOLD, RODRIGUEZ MARTHA E, HILTON MICHAEL CHRISTOPHER, PAIK SPENCER, FISCHER JOHANN PETER
• Format: Patent
• Language: Chinese; English
• Published: 10.06.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds, and methods of use thereof. 本发明涉及抑制KRas G12D的化合物。具体地，本发明涉及抑制KRas G12D活性的化合物、包含所述化合物的药物组合物以及其使用方法。