Intranasal spray for delivering exosome through thermosensitive hydrogel for treating nervous system diseases

• Main Authors: WANG RENJIE, ZHAO FANGQIAN, WANG FEI, SONG CAIXIA, YIN XIAOGUANG, LI YUNFENG, WAN MINGWU, NIE DAIBANG
• Format: Patent
• Language: Chinese; English
• Published: 10.06.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an intranasal spray for delivering exosomes by using thermosensitive hydrogel, which is used for treating nervous system diseases and comprises the following raw material components in parts by mass: 1-10 parts of chitosan, 1-10 parts of chitosan and 1-10 parts of chitosan. Comprising the following components in parts by weight: 12 parts of an absorption enhancer, 1.5 parts of a stabilizer, 6 parts of radix saposhnikoviae, 0.5 part of a preservative, 7 parts of radix angelicae, 1 part of an isoosmotic adjusting agent, 5 parts of herba schizonepetae, 7 parts of radix aconiti lateralis preparata, 15 parts of scopolamine hydrobromide, 9 parts of rhizoma zingiberis, 5 parts of fructus xanthii, 16 parts of H102 peptide, 6 parts of flos magnoliae liliflorae and 4 parts of fried scutellaria baicalensis. The traditional Chinese medicines such as the radix saposhnikoviae, the radix angelicae, the herba schizonepetae, the radix aconiti lateralis preparata and the rhizoma zingiberis need to be de