Application of kynurenic acid in preparation of medicine for improving HIV-1 (human immunodeficiency virus-1) related neurocognitive impairment

• Main Authors: GONG ZELONG, LI YUBIN, LUN JINGXIAN, GAO XUEFENG, CAO HONG
• Format: Patent
• Language: Chinese; English
• Published: 10.06.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention discloses an application of kynurenic acid in preparation of a medicine for improving HIV-1 (human immunodeficiency virus-1) related neurocognitive impairment. Tryptophan metabolites comprise kynurenic acid or pharmaceutically acceptable salts of kynurenic acid. According to the application disclosed by the invention, through in-vitro and in-vivo tests, the inventor effectively shows that a specific dose of kynurenic acid can effectively inhibit inflammatory response and apoptosis of nerve cells caused by HIV-1gp120, repair nerve cell injury, relieve brain tissue injury and improve cognitive impairment caused by HAND, so that the kynurenic acid has the effect of remarkably improving HAND symptoms complicated by HIV. 本发明公开了犬尿喹啉酸在制备改善HIV-1相关神经认知功能障碍药物中的应用，所述色氨酸代谢产物包括犬尿喹啉酸或其药学上可接受的盐。在本发明中，发明人通过体外和体内试验，有效的说明了特定剂量的犬尿喹啉酸能够有效抑制HIV-1gp120导致的神经细胞的炎症反应和凋亡，修复神经细胞损伤，减轻脑组织损伤，改善HAND造成的认知障碍，从而具有显著改善HIV并发的HAND症状的作用。