Benzo-aza compound and synthesis method thereof

• Main Authors: WU TIANZHI, WANG BICHUAN, ZHU JIN, TANG YUJIANG, WU KE, ZHOU QINGFA, HAO SIYUAN, HAN FANG
• Format: Patent
• Language: Chinese; English
• Published: 07.06.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the field of organic chemistry, and particularly relates to a benzo-aza compound and a synthesis method thereof. According to the method, isatin azomethine imine, allenoic acid ester or acetylenic acid ester and acetylenic ketone are dissolved in a dimethyl sulfoxide solvent, triphenylphosphine which is low in price and easy to obtain serves as a catalyst, reaction is conducted for 8 hours, the benzazepine compound is obtained, and the compound has potential pharmaceutical application value. The synthesis method has the advantages of wide substrate application range, simplicity and convenience in operation, mild reaction, convenience in post-treatment, simplicity and easiness in obtaining of raw materials and catalysts and the like. 本发明属于有机化学领域，具体涉及一种苯并氮杂䓬化合物及其合成方法。本方法将靛红偶氮次甲基亚胺和联烯酸酯或炔酸酯、炔酮溶于二甲亚砜溶剂中，以廉价易得的三苯基膦为催化剂，反应8小时，得到一种苯并氮杂䓬化合物，该类化合物具有潜在的药学应用价值。本发明合成方法具有底物适用面广，操作简便、反应温和、后处理方便、原料和催化剂简单易得等优点。