Osteosynthetic compounds

Disclosed herein are compounds having the following formula (I) or pharmaceutically acceptable salt forms thereof: B-L-C (I) wherein B is a bone binding moiety; l is a linker; and C is a cationic steroidal antimicrobial (CSA) moiety, pharmaceutical compositions comprising the compounds, and methods...

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Bibliographic Details
Main Authors VALCHEV PETER, SAVAGE PAUL B, SCHINDLER AARON, KAMBLE, SOMAD
Format Patent
LanguageChinese
English
Published 03.06.2022
Subjects
DIAGNOSIS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
MEDICAL OR VETERINARY SCIENCE
SURGERY
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Summary:Disclosed herein are compounds having the following formula (I) or pharmaceutically acceptable salt forms thereof: B-L-C (I) wherein B is a bone binding moiety; l is a linker; and C is a cationic steroidal antimicrobial (CSA) moiety, pharmaceutical compositions comprising the compounds, and methods of using the compounds or pharmaceutical compositions for treating infection or osteomyelitis in the bone of a subject, promoting bone formation in a subject, or treating bone cancer or metastatic bone cancer in a subject. 本文中公开了具有下式(I)的化合物或其可药用盐形式：B-L-C(I)，其中B是骨结合部分；L是接头；并且C是阳离子甾体抗微生物(CSA)部分，包含所述化合物的药物组合物，以及使用所述化合物或药物组合物用于在对象的骨中治疗感染或骨髓炎、在对象中促进骨形成或在对象中治疗骨癌或转移性骨癌的方法。
Bibliography:Application Number: CN202080066011