Indoloquinoline derivative as well as preparation method and application thereof

The invention relates to an indoloquinoline derivative as well as a preparation method and application thereof. The indoloquinoline derivative is a compound as shown in a formula I or a formula II, or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitrogen oxide, a hydrate, a solvate...

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Bibliographic Details
Main Authors LU LIANGQIU, XIAO YUQING, XIAO WENJING, LI YUJIE
Format Patent
LanguageChinese
English
Published 31.05.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to an indoloquinoline derivative as well as a preparation method and application thereof. The indoloquinoline derivative is a compound as shown in a formula I or a formula II, or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitrogen oxide, a hydrate, a solvate and a pharmaceutically acceptable salt of the compound as shown in the formula I or the formula II. The 10 # site modified indoloquinoline compound and the compound prepared from the 10 # site modified indoloquinoline compound have good anti-cancer activity, and the preparation method is simple and efficient. 本发明涉及一种吲哚并喹啉衍生物及其制备方法和应用，吲哚并喹啉衍生物为所述化合物为式I或式II所示化合物，或者为式I或式II所示化合物的立体异构体、几何异构体、互变异构体、消旋体、氮氧化物、水合物、溶剂化物、药学上可接受的盐。基于本发明的10号位修饰的吲哚并喹啉类化合物及由其制备得到的化合物具有良好的抗癌活性，且制备方法简单、高效。
Bibliography:Application Number: CN202210238611