Identification of one or more compounds for targeting genes

• Main Author: SELWOOD MATTHEW
• Format: Patent
• Language: Chinese; English
• Published: 27.05.2022
• Subjects: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS

A computer-implemented method of identifying a tool compound is provided. The method comprises: searching a database for first candidate compounds each targeting one or more first target genes; generating a first fingerprint for each first candidate compound by searching the database for a gene associated with the first candidate compound and predicting the gene associated with the first candidate compound; and filtering the first candidate compound using the first fingerprint to identify a first optimized compound targeting the one or more first target genes. 提供了鉴定工具化合物的计算机实施的方法。该方法包括：在数据库中搜索每个都靶向一个或多个第一靶基因的第一候选化合物；通过以下方式为每个第一候选化合物生成第一指纹：在所述数据库中搜索与第一候选化合物相关的基因，并预测与第一候选化合物相关的基因；和利用第一指纹过滤第一候选化合物，以鉴定出靶向所述一个或多个第一靶基因的第一优化化合物。