个人化癌症免疫治疗

• Format: Patent
• Language: Chinese
• Published: 17.06.2025
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

本发明关于一种获得特异性结合于肿瘤样本及针对肿瘤样本之抗体或其抗原结合片段之方法，所述方法包含：向个体投与自体树突状细胞；自所述个体获取免疫细胞及肿瘤样本；建构所述免疫细胞之抗体库；及筛选所述抗体库以获得特异性结合于所述肿瘤样本及针对所述肿瘤样本之所述抗体或其片段。本发明亦关于一种用于改造免疫细胞、特异性结合于肿瘤样本及针对肿瘤样本之抗体或其抗原结合片段之方法及其用途。 The present disclosure relates to a method for obtaining an antibody or antigen-binding fragment thereof that specifically binds to and against a tumor sample, comprising: administering autologous dendritic cells to a subject; taking immune cells and a tumor sample from the subject; constructing an antibody library of the immune cells; and screening the antibody library to obtain the antibody or a fragment thereof specifically binding to and against the tumor sample. The disclosure also relates to a method for engineering immune cells, an antibody or antigen-binding fragment thereof that specifically binds to and against a tumor sample and uses thereof.