Increasing genomic stability and reprogramming efficiency of induced pluripotent stem cells

The present disclosure relates to methods and compositions for producing induced pluripotent stem cells with improved efficiency and genomic stability. In particular aspects, induced pluripotent stem cells are produced from somatic cells after inhibiting, lowering, or down-regulating a particular pr...

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Bibliographic Details
Main Authors GEORGIEVA DIANA, EGLI DIETER
Format Patent
LanguageChinese
English
Published 13.05.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present disclosure relates to methods and compositions for producing induced pluripotent stem cells with improved efficiency and genomic stability. In particular aspects, induced pluripotent stem cells are produced from somatic cells after inhibiting, lowering, or down-regulating a particular protein or gene. In some embodiments, the protein is a p53-binding protein or 53BP1. 本公开涉及用于产生具有提高的效率和基因组稳定性的诱导性多能干细胞的方法和组合物。在特定方面，在抑制、降低或下调特定蛋白质或基因之后，从体细胞产生诱导性多能干细胞。在一些实施方案中，所述蛋白质是p53-结合蛋白或53BP1。
Bibliography:Application Number: CN202080066625