Derivative for eliminating 1-position hydroxyl of oridonin and application thereof

• Main Authors: LI JUNDA, WU HONGYU, XU SHENGTAO, XIE SHAOWEN, YAO HONG, LIU JUNKAI, XU JINYI
• Format: Patent
• Language: Chinese; English
• Published: 13.05.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a derivative for eliminating 1-position hydroxyl of oridonin and application, the structure of the derivative is shown in the specification, and the invention provides a new compound with tri-negative breast cancer resisting activity by further modifying the structure of oridonin. Compared with oridonin, the compound disclosed by the invention not only can well inhibit the growth of triple-negative breast cancer cells, but also has better selectivity and lower toxicity. 本发明公开了消除冬凌草甲素1位羟基的衍生物及用途，结构如下，本发明通过对冬凌草甲素进行进一步结构修饰改造，提供一类具有抗三阴乳腺癌活性的新化合物。与冬凌草甲素相比，本发明的化合物不仅能很好的抑制三阴乳腺癌细胞生长，且具有更好的选择性，更低的毒性。