Method for preparing N-methyl-2-pyrrolidine ethylamine or salt thereof

The present invention provides a process for the preparation of N-methyl-2-pyrrolidine ethylamine or a salt thereof, the process comprising the steps of c) reacting a compound IV with a compound V to produce a compound VI, d) removing Boc from the compound VI to obtain a compound I, i.e. N-methyl-2-...

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Bibliographic Details
Main Authors XU WANBIN, JIANG DEHUI, ZHU FUQIANG
Format Patent
LanguageChinese
English
Published 13.05.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a process for the preparation of N-methyl-2-pyrrolidine ethylamine or a salt thereof, the process comprising the steps of c) reacting a compound IV with a compound V to produce a compound VI, d) removing Boc from the compound VI to obtain a compound I, i.e. N-methyl-2-pyrrolidine ethylamine. The synthetic route has the advantages of high yield, few byproducts, greenness, economy and the like, and is suitable for being developed into an industrial production process. 本发明提供了一种制备N-甲基-2-吡咯烷乙胺或其盐的方法，该方法包括以下步骤：c)使化合物IV与化合物V反应以生成化合物VI，d)使化合物VI脱Boc以得到化合物I，即N-甲基-2-吡咯烷乙胺。该合成路线具有产率高，副产物少，绿色经济等优点，适合于开发为工业化生产工艺。
Bibliography:Application Number: CN202011255963