Asymmetric preparation method of pyridinol nitrogen oxide

• Main Authors: DING XIAOBING, GAO SHUANG, SU WEI, LANG QIWEI
• Format: Patent
• Language: Chinese; English
• Published: 13.05.2022
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention discloses a preparation method of pyridinol nitrogen oxide, and particularly relates to a method for preparing pyridinol nitrogen oxide by catalyzing asymmetric hydrogenation of pyridone nitrogen oxide through a chiral ferrocene metal complex. The method is simple in step, simple and convenient to operate, mild in condition and wide in substrate application range, the dosage of the catalyst can be only 0.001 mol% (S/C = 100000), a series of pyridinol compounds can be efficiently and asymmetrically synthesized through one-step reduction deoxidation, and the method has huge industrial application value. 本发明公开了一种吡啶醇氮氧化物的制备方法，具体为通过手性二茂铁金属络合物催化吡啶酮氮氧化物不对称氢化制备吡啶醇氮氧化物的方法。该方法步骤简单，操作简便，条件温和，底物适用范围广，催化剂用量可以仅为0.001mol％(S/C＝100000)，再经过一步还原脱氧，可以高效不对称合成一系列吡啶醇类化合物，具有巨大的工业应用价值。