Method for detecting memantine hydrochloride in memantine hydrochloride tablet

• Main Authors: LIU JIE, LI BILU, HUANG JUNPENG
• Format: Patent
• Language: Chinese; English
• Published: 06.05.2022
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a method for detecting memantine hydrochloride in memantine hydrochloride tablets, which specifically adopts a high performance liquid chromatograph to be matched with a differential refraction detector, adopts a buffer solution with pH of 6.0 (taking 2ml of diethylamine, adding water, uniformly mixing, and adjusting the pH value to 6.0 with glacial acetic acid)-methanol solution as a mobile phase, and adopts octadecyl bonded silica gel as a filler of a chromatographic column. A proper amount of memantine hydrochloride is taken, a buffer solution with the pH of 6.0, 0.2% NaCl and methanol are added for preparation, a 0.45 m PVDF filter membrane is used for filtration, 3 ml of primary filtrate is discarded, subsequent filtrate is taken to obtain a test solution, the theoretical plate number of a main peak of the reference solution is 2552, and the tailing factor is 1.7. The quantitative detection method for memantine hydrochloride in the memantine hydrochloride tablet overcomes the defe