Preparation method of cyclopropane derivative

The invention belongs to the technical field of organic chemical synthesis, and discloses a preparation method of a cyclopropane derivative, which comprises the following steps: 1) adding a drying agent into a pyrazoline compound, mixing, standing, separating liquid, and collecting supernatant liqui...

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Bibliographic Details
Main Authors XIANG KAI, ZHANG HANJIE, ZHANG XING, FANG TAO, SUN HAIYUN, WANG JINGQI, JIANG RONGPEI
Format Patent
LanguageChinese
English
Published 06.05.2022
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention belongs to the technical field of organic chemical synthesis, and discloses a preparation method of a cyclopropane derivative, which comprises the following steps: 1) adding a drying agent into a pyrazoline compound, mixing, standing, separating liquid, and collecting supernatant liquid to obtain a dried pyrazoline compound; 2) adding a catalyst into the dried pyrazoline compound, and mixing to obtain a reaction solution; 3) heating the reaction liquid until the temperature of the reaction liquid reaches 180-190 DEG C, and starting to collect condensate generated by distillation; 4) continuously heating the reaction liquid to 200-210 DEG C, and preserving heat until no condensate is generated; and 5) continuously heating the reaction liquid to 230-240 DEG C, preserving heat until no condensate is generated, and collecting the condensate, namely the target product. The preparation method disclosed by the invention is simple in process condition, high in reaction yield, less in three wastes genera
Bibliography:Application Number: CN202210019480