Application of flavonoid compound in preparation of medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome

• Main Author: WEN YAOLIN
• Format: Patent
• Language: Chinese; English
• Published: 06.05.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of medicine research and development, in particular to application of a flavonoid compound in preparation of a medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome, the flavonoid compound has a structure as shown in a formula I, r1 is selected from H, a hydroxyl group, an alkyl group of C1-C8, a cycloalkyl group of C3-C10, an alkoxy group of C1-C8 and a glycosyl residue of C4-C20; r2 and R3 are independently selected from one of H, a hydroxyl group, an alkyl group of C1-C8, a cycloalkyl group of C3-C10 and an alkoxy group of C1-C8; and R4 is selected from an aryl group of C5-C20 or a substituted aryl group of C5-C20. The flavonoid compound can obviously relieve inflammatory response of mice with acute lung injury, reduce the ratio of wet weight to dry weight of lungs, inhibit lung edema caused by acute lung injury while resisting inflammation, and can be used as a potential medicine for preventing or treating acute lung i