Application of isopentenyl flavonoid compound in preparation of medicine

• Main Authors: CHEN JIALING, WEN YAOLIN
• Format: Patent
• Language: Chinese; English
• Published: 06.05.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of medicine research and development, in particular to application of an isopentenyl flavonoid compound in preparation of a medicine, the medicine can be used for preventing or treating acute lung injury and/or acute respiratory distress syndrome, the isopentenyl flavonoid compound has a structure as shown in a formula 1, and definitions of R1-R10, M, X and k are recorded in the specification. The isopentenyl flavonoid compound provided by the invention can obviously inhibit inflammatory response, inhibit release of inflammatory factors, reduce the content of inflammatory factors in alveolar lavage fluid and serum, and also can obviously inhibit pulmonary edema, reduce generation of pulmonary effusion and reduce wet weight of lungs, so that the lung quality is improved. The increasing degree of the ratio of wet weight to dry weight of lung caused by acute lung injury is inhibited, so that the effects of resisting inflammation and inhibiting lung edema are achieved.