PHARMACEUTICAL COMPOSITIONS COMPRISING OXOISOINDOLE COMPOUNDS AND METHODS OF USING SAME

• Main Authors: AGRAWAL, ANJALI, VISKY DORA, THOR, PRAJWAL, GANGVAS, XIE RUIMIN, KARKI SHYAM BABU, CHEN MINGZHANG
• Format: Patent
• Language: Chinese; English
• Published: 29.04.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are pharmaceutical compositions (e.g., orally administered formulations) comprising (S)-4-(4-(4-(((2-(2, 6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl) oxy) methyl) benzyl) piperazin-1-yl)-3-fluorobenzonitrile or an enantiomer, a mixture of enantiomers, a tautomer, an isotopic body, or a pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of making the pharmaceutical compositions and methods of using the pharmaceutical compositions. 本文提供了药物组合物(例如，经口给药制剂)，其包含(S)-4-(4-(4-(((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-4-基)氧基)甲基)苄基)哌嗪-1-基)-3-氟苄腈或其对映异构体、对映异构体的混合物、互变异构体、同位素体或药学上可接受的盐，以及载体或稀释剂。本文还提供了制备所述药物组合物的方法以及使用所述药物组合物的方法。