Preparation method of 2-cyanobenzaldehyde and derivatives thereof

• Main Authors: ZHAO NA, BU YANBING, SUN YUANYUAN, ZHOU QINGQING, TAN XIN, LI JINGU
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

A preparation method of 2-cyanobenzaldehyde and derivatives thereof belongs to the field of preparation of drug intermediates, and comprises the following steps: sequentially adding a palladium catalyst, a ligand and an acid-binding agent into a reaction solvent, then adding o-halogenated cyanobenzene and derivatives thereof, and paraformaldehyde, stirring and heating to 80-110 DEG C, reacting for 6-24 hours, filtering, washing, and drying to obtain 2-cyanobenzaldehyde. And carrying out post-treatment to obtain the high-purity 2-cyanobenzaldehyde and the derivative thereof. The preparation method disclosed by the invention is green and environment-friendly, the utilization rate of initial raw materials is relatively high, the reaction yield is relatively high, and the reaction conditions are mild; the use of high-toxicity and high-risk reaction materials such as chlorine and cyanide used in the prior art is avoided; according to the 2-cyanobenzaldehyde and the derivative thereof prepared by the method disclos