Preparation method of 2-cyanobenzaldehyde and derivatives thereof

A preparation method of 2-cyanobenzaldehyde and derivatives thereof belongs to the field of preparation of drug intermediates, and comprises the following steps: sequentially adding a palladium catalyst, a ligand and an acid-binding agent into a reaction solvent, then adding o-halogenated cyanobenze...

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Bibliographic Details
Main Authors ZHAO NA, BU YANBING, SUN YUANYUAN, ZHOU QINGQING, TAN XIN, LI JINGU
Format Patent
LanguageChinese
English
Published 26.04.2022
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:A preparation method of 2-cyanobenzaldehyde and derivatives thereof belongs to the field of preparation of drug intermediates, and comprises the following steps: sequentially adding a palladium catalyst, a ligand and an acid-binding agent into a reaction solvent, then adding o-halogenated cyanobenzene and derivatives thereof, and paraformaldehyde, stirring and heating to 80-110 DEG C, reacting for 6-24 hours, filtering, washing, and drying to obtain 2-cyanobenzaldehyde. And carrying out post-treatment to obtain the high-purity 2-cyanobenzaldehyde and the derivative thereof. The preparation method disclosed by the invention is green and environment-friendly, the utilization rate of initial raw materials is relatively high, the reaction yield is relatively high, and the reaction conditions are mild; the use of high-toxicity and high-risk reaction materials such as chlorine and cyanide used in the prior art is avoided; according to the 2-cyanobenzaldehyde and the derivative thereof prepared by the method disclos
Bibliography:Application Number: CN202210291637